Methyl iodide → 2-Methyl-3-(n-butyl)-1-(2-morpholinophenyl)-2-thiopseudourea hydroiodide

HRID 1492241

Reaction equation

HRID 1492241 reaction equation
[CH2:1]([NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[S:7])[CH2:2][CH2:3][CH3:4].[CH3:21][I:22]>CC(C)=O>[IH:22].[CH3:21][S:7][C:6](=[N:5][CH2:1][CH2:2][CH2:3][CH3:4])[NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 86252541-(n-Butyl)-3-(2-morpholinophenyl)thiourea

Product 1

HCID 189521352-Methyl-3-(n-butyl)-1-(2-morpholinophenyl)-2-thiopseudourea hydroiodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 1-(n-butyl)-3-(2-morpholinophenyl)thiourea (5.8 g) and methyliodide (3.1 g) in acetone (25 ml) was heated at reflux for 4 hours to yield 2-methyl-3-(n-butyl)-1-(2-morpholinophenyl)-2-thiopseudourea hydroiodide as a colourless solid m.p. 154°-156° C.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 4 hours

Sources & evidence

ORD record
ord-ca5e95bd8be44316bca6fce21dc6827f
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Linked notes

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