HCID 15143423, compound → HCID 13685437, compound
Reaction equation
C([O:8][CH2:9][C@H:10]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH3:11])C1C=CC=CC=1>[Pd].C(O)C>[CH2:13]([O:12][C@H:10]([CH3:11])[CH2:9][OH:8])[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture liquid of the above (R)-1-benzyloxy-2-hexyloxy-propane (25 g),palladium/carbon catalyst (2.0 g) and ethanol (200 ml) was subjected to hydrogenolysis. After completion of the reaction, the catalyst was filtered off, followed by concentrating the mother liquor, and distilling the concentrate under reduced pressure to obtain (R)-2-hexyloxy-1-propanol (b.p. 67°-68° C./4 mmHg) (11.6 g).
Workup
- customAfter completion of the reaction
- filtrationthe catalyst was filtered off
- concentrationby concentrating the mother liquor
- distillationdistilling the
- concentrationconcentrate under reduced pressure
Sources & evidence
- ORD record
- ord-5d31cdb1a6644ed2a51519e74e855cb6
- Source dataset
- uspto-grants-1991_06
- Patent number
- US05021191
Reaction notes
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