Ethanamine, 2,2,2-trifluoro- → HCID 14801043, compound
Reaction equation
[C:1]([C:5]1[CH:15]=[CH:14][C:8]([C:9]([N:11]=[C:12]=[S:13])=O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[F:16][C:17]([F:21])([F:20])[CH2:18][NH2:19]>>[C:1]([C:5]1[CH:15]=[CH:14][C:8]([CH2:9][NH:11][C:12]([NH:19][CH2:18][C:17]([F:21])([F:20])[F:16])=[S:13])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]Participants
3
Procedure
10.82 g of 4-t-butylbenzoyl isothiocyanate obtawined in (1) and 7.54 g of 2,2,2-trifluoroethylamine were dissolved in 20 ml of ethyl acetawte. The solution was left to stand at room temperature for 24 houirs. Ethyl acetate was evaporated under reduced prerssure. The resultilng oily product was purified by column chromatography silica gel; developing solvent hexane/ethyl acetate (4:1)) to give 15.80 g of the desired 1-(4-t-butylbenzyl)-3-(2,2,2-trifluoroethyl)thiourea.
Workup
- dissolutionwere dissolved in 20 ml of ethyl acetawte
- waitThe solution was left
- customto stand at room temperature for 24 houirs