2-Benzyl-5-ethylaminoisoindoline → 5-Ethylaminoisoindoline
Reaction equation
C([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([NH:17][CH2:18][CH3:19])[CH:14]=2)[CH2:9]1)C1C=CC=CC=1>[Pd].CO>[CH2:18]([NH:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:16]2)[CH3:19]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
400 mg of 10% palladium on carbon was added to 2.17 g of 2-benzyl-5-ethylaminoisoindoline prepared above in 30 ml of methanol and catalytic hydrogenation was carried out at 45° C. for 7 days. After removing the catalyst by filtration, the filtrate was concentrated and purified by vacuume distillation (bath temperature: 160°-200° C., pressure: 0.1 mmHg) to obtain 950 mg of 5-ethylaminoisoindoline.
Workup
- customAfter removing the catalyst
- filtrationby filtration
- concentrationthe filtrate was concentrated
- distillationpurified by vacuume distillation (bath temperature: 160°-200° C., pressure: 0.1 mmHg)
Sources & evidence
- ORD record
- ord-a4dc9e666953490bbe4d2a1c421461c5
- Source dataset
- uspto-grants-1991_06
- Patent number
- US05026856
Reaction notes
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