N-Iodosuccinimide → HCID 117600656, compound
Reaction equation
[CH3:1][O:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1.[I:9]N1C(=O)CCC1=O>CC(O)=O>[I:9][C:7]1[C:3]([O:2][CH3:1])=[N:4][O:5][C:6]=1[CH3:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 60 °C
Procedure
To a solution of 3-Methoxy-5-methyl-isoxazole (0.60 g, 5.0 mmol) in AcOH (15 mL) is added N-iodosuccinimide (1.10 g, 5.00 mmol) at 60° C. under nitrogen. Then the reaction mixture is stirred at 60° C. for 2 h. The mixture is concentrated in vacuo to give an oil. This oil is purified by column chromatography on silica gel to give the desired compound.
Workup
- concentrationThe mixture is concentrated in vacuo
- customto give an oil
- customThis oil is purified by column chromatography on silica gel
Sources & evidence
- ORD record
- ord-5096fc4612af49eba601f5debdcd0d7f
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09199988B2
Reaction notes
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