Hydrazine hydrate (1:1) → HCID 68642532, compound

HRID 1498933

Reaction equation

HRID 1498933 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:10][C:11]([C:15]([O:17]CC)=O)=[C:12]([CH3:14])[N:13]=1.O.[NH2:21][NH2:22]>C(O)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[S:10][C:11]([C:15]([NH:21][NH2:22])=[O:17])=[C:12]([CH3:14])[N:13]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58657933Ethyl 2-(2,4-dichlorophenyl)-4-methyl-1,3-thiazole-5-carboxylate

Product 1

HCID 68642532HCID 68642532, compoundYield 88.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-(2,4-dichlorophenyl)-4-methylthiazole-5-carboxylate (250 mg) prepared in the Step 23-1-1 was dissolved in ethanol (10 ml), and hydrazine monohydrate (794 mg) was added thereto. The mixture was heated under reflux for 23 hours. After the mixture was allowed to cool, the precipitated crystal was separated by filtration, washed with water, and dried to give 2-(2,4-dichlorophenyl)-4-methylthiazole-5-carboxylic acid hydrazide (211 mg, 88%).

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 23 hours
  3. temperatureto cool
  4. customthe precipitated crystal was separated by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-8094eb14aecd4fe688b54e3ac0a66359
Source dataset
uspto-grants-2015_12
Patent number
US09200008B2

Linked notes

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