Pyrimidine, 2-ethynyl-4-methoxy- (9CI) → HCID 71743828, compound

Reaction equation

[F:1][C:2]1[C:3]([O:14][CH3:15])=[N:4][C:5]([C:8]#[C:9][Si](C)(C)C)=[N:6][CH:7]=1.C(C1N=C(OC)C=CN=1)#C>>[C:8]([C:5]1[N:4]=[C:3]([O:14][CH3:15])[C:2]([F:1])=[CH:7][N:6]=1)#[CH:9]

Participants

Reactant 2

HCID 10011938Pyrimidine, 2-ethynyl-4-methoxy- (9CI)

HCID 67327167HCID 67327167, compound

Product 1

HCID 71743828HCID 71743828, compound

Procedure

Obtained (82%) from 5-fluoro-4-methoxy-2-((trimethylsilyl)ethynyl)pyrimidine (Preparation 16b) following the experimental procedure as described in Preparation 1b followed by purification by flash chromatography (99:1 dichloromethane/methanol).

Workup

customfollowed by purification by flash chromatography (99:1 dichloromethane/methanol)

Sources & evidence

ORD record: ord-8478145a147f4cda96e93b0888abb220
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09206183B2

Reaction notes

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