Nitric Acid → HCID 21730694, compound
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([F:10])[C:3]=1[F:11].[N+:12]([O-])([OH:14])=[O:13].O>C(O)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([N+:12]([O-:14])=[O:13])[C:5]([O:8][CH3:9])=[C:4]([F:10])[C:3]=1[F:11]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 60 °C
Procedure
To a solution of 1,2,3-trifluoro-4-methoxybenzene (1.6 g, 10 mmol) in acetic acid (20 mL) was added nitric acid (5 mL) and the mixture was heated at 60° C. for 3 hours. After cooling to ambient temperature, water (100 mL) was added and the mixture was extracted with ethyl acetate (3×100 mL). The organic layers were concentrated to give the crude title compound, which was used in the next step without further purification.
Workup
- temperatureAfter cooling to ambient temperature
- extractionthe mixture was extracted with ethyl acetate (3×100 mL)
- concentrationThe organic layers were concentrated
Sources & evidence
- ORD record
- ord-c2c390d360d84a968080b3771ad37834
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09212192B2
Reaction notes
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