Dimethyl Sulfoxide → N-(3-((2-(4-(1-hydroxyethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide

HRID 150669

Reaction equation

HRID 150669 reaction equation
[CH3:36][S:37]([CH3:38])=[O:39].[Cl:1][c:2]1[n:3][cH:4][c:5]([C:22]([F:23])([F:24])[F:25])[c:6]([NH:8][CH2:9][c:10]2[c:11]([N:16]([S:17](=[O:18])(=[O:19])[CH3:20])[CH3:21])[n:12][cH:13][cH:14][cH:15]2)[n:7]1.[NH2:26][c:27]1[cH:28][cH:29][c:30]([CH:33]([CH3:34])[OH:35])[cH:31][cH:32]1>>[c:2]1([NH:26][c:27]2[cH:28][cH:29][c:30]([CH:33]([CH3:34])[OH:35])[cH:31][cH:32]2)[n:3][cH:4][c:5]([C:22]([F:23])([F:24])[F:25])[c:6]([NH:8][CH2:9][c:10]2[c:11]([N:16]([S:17](=[O:18])(=[O:19])[CH3:20])[CH3:21])[n:12][cH:13][cH:14][cH:15]2)[n:7]1

Participants

4

Reactant 3

HCID 679Dimethyl SulfoxideHCID 857534-Amino-alpha-methylbenzenemethanolHCID 57584561N-(3-((2-chloro-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide

Product 1

HCID 25117123N-(3-((2-(4-(1-hydroxyethyl)phenylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide

Sources & evidence

ORD record
ord-bc57faaa770640688045ee98e40677fc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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