Ethyl 2-formylpyridine-4-carboxylate → HCID 90374998, compound
Reaction equation
[CH:1]([C:3]1[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][N:4]=1)=O.[CH3:14][N:15]([CH2:17][CH:18]1[CH2:23][CH2:22][CH:21]([CH2:24][NH2:25])[CH2:20][CH2:19]1)[CH3:16]>>[CH3:16][N:15]([CH2:17][CH:18]1[CH2:23][CH2:22][CH:21]([CH2:24][NH:25][CH2:1][C:3]2[CH:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][N:4]=2)[CH2:20][CH2:19]1)[CH3:14]Participants
3
Procedure
By General Procedure A from ethyl 2-formylpyridine-4-carboxylate and {4-[(dimethylamino)methyl]cyclohexyl}methanamine. Aqueous work up gave the title compound as a yellow oil. Used without further purification. 1H NMR (300 MHz, chloroform-d): δ ppm 8.41 (d, 1H), 8.04 (s, 1H), 7.49 (d, 1H), 4.04 (q, 2H), 3.39 (s, 2H), 2.46 (m, 4H), 2.38 (d, 6H), 1.60 (m, 4H), 1.34 (t, 3H), 1.03 (m, 2H), 0.68 (m, 4H).
Sources & evidence
- ORD record
- ord-a32ef5bcf602421a8c13474aa62f62c3
- Source dataset
- uspto-grants-2015_12