4-Methylnicotinic acid → HCID 73425619, compound

Reaction equation

[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:14])([CH3:13])[C:7](=[O:12])[N:8]2[CH3:11])=[CH:4][CH:3]=1.[CH3:15][C:16]1[C:21]([C:22](O)=[O:23])=[CH:20][N:19]=[CH:18][CH:17]=1>>[CH3:15][C:16]1[C:21]([C:22]([NH:1][C:2]2[CH:10]=[C:9]3[C:5]([C:6]([CH3:14])([CH3:13])[C:7](=[O:12])[N:8]3[CH3:11])=[CH:4][CH:3]=2)=[O:23])=[CH:20][N:19]=[CH:18][CH:17]=1

Participants

Reactant 2

HCID 2291634-Methylnicotinic acid

HCID 529112486-Amino-1,3,3-trimethyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 73425619HCID 73425619, compound

Procedure

Prepared in analogy to example 1b from 6-amino-1,3,3-trimethylindolin-2-one and 4-methylnicotinic acid. The title compound was obtained as red oil.

Sources & evidence

ORD record: ord-1485186cc6f549ac9f273c2c8b37df6c
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09221816B2

Reaction notes

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