3-Chloropyridine-4-carboxylic acid → 3-Chloro-N-(1-cyclopropyl-3,3-dimethyl-2-oxoindolin-6-yl)isonicotinamide
Reaction equation
[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:26])([CH3:25])[C:17](=[O:24])[N:18]2[CH:21]2[CH2:23][CH2:22]2)=[CH:14][CH:13]=1>>[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:26])([CH3:25])[C:17](=[O:24])[N:18]2[CH:21]2[CH2:22][CH2:23]2)=[CH:14][CH:13]=1)=[O:6]Participants
3
Procedure
Prepared in analogy to example 26 from 3-chloroisonicotinic acid and 6-amino-1-cyclopropyl-3,3-dimethyl-1,3-dihydro-indol-2-one (example 14c). The title compound was obtained as white foam.
Sources & evidence
- ORD record
- ord-a828bdbf0e664e8597a93931f2b5849f
- Source dataset
- uspto-grants-2015_12