Furo[2,3-C]pyridin-3(2H)-one → furo[2,3-c]pyridin-3(2H)-one O-methyl oxime

Reaction equation

[CH3:1][O:2][N:3]=[C:4]1[C:12]2[CH:11]=[CH:10][N:9]=N[C:7]=2[O:6][CH2:5]1.O1C2=CN=CC=C2C(=O)[CH2:14]1>>[CH3:1][O:2][N:3]=[C:4]1[C:12]2[C:7](=[CH:14][N:9]=[CH:10][CH:11]=2)[O:6][CH2:5]1

Participants

Reactant 2

HCID 14199080Furo[2,3-C]pyridin-3(2H)-one

HCID 86721901furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime

Product 1

HCID 86721903furo[2,3-c]pyridin-3(2H)-one O-methyl oxime

Procedure

This compound was prepared using a method analogous to that of furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime (A.2.3.3), furo[2,3-c]pyridin-3(2H)-one replacing furo[2,3-c]pyridazin-5(6H)-one. Purification by CC (KP-SIL™ from Biotage) using Hept/EtOAc (1/1) gives the desired product as brown solid;

Workup

customThis compound was prepared
customPurification by CC (KP-SIL™ from Biotage)

Sources & evidence

ORD record: ord-ba55681e73e84b38aa04acaae529dc5a
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09221832B2

Reaction notes

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