5,6-Dihydrofuro[2,3-c]pyridazin-5-amine → 7-Cyclopropyl-2,3-dihydrofuro[2,3-c]pyridin-3-amine

Reaction equation

N1C2OCC(N)C=2C=CN=1.CO[N:13]=[C:14]1[C:22]2[C:17](=[C:18]([CH:23]3[CH2:25][CH2:24]3)[N:19]=[CH:20][CH:21]=2)[O:16][CH2:15]1>>[CH:23]1([C:18]2[N:19]=[CH:20][CH:21]=[C:22]3[CH:14]([NH2:13])[CH2:15][O:16][C:17]=23)[CH2:25][CH2:24]1

Participants

Reactant 2

HCID 867219025,6-Dihydrofuro[2,3-c]pyridazin-5-amine

HCID 867219107-cyclopropylfuro[2,3-c]pyridin-3(2H)-one O-methyl oxime

Product 1

HCID 867219117-Cyclopropyl-2,3-dihydrofuro[2,3-c]pyridin-3-amine

Procedure

This compound was prepared using a method analogous to that of 5,6-dihydrofuro[2,3-c]pyridazin-5-amine (A.2.3.4), 7-cyclopropylfuro[2,3-c]pyridin-3(2H)-one O-methyl oxime replacing furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime;

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-02f6584b72b047df99e753ea2a2137d0
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09221832B2

Reaction notes

Loading…