6-Methyl-furo[2,3-B]pyridin-3-one → 6-methylfuro[2,3-b]pyridin-3(2H)-one O-methyl oxime

Reaction equation

[CH3:1][O:2][N:3]=[C:4]1[C:12]2[CH:11]=[CH:10]N=[N:8][C:7]=2[O:6][CH2:5]1.[CH3:13][C:14]1N=C2OCC(=O)C2=CC=1>>[CH3:1][O:2][N:3]=[C:4]1[C:12]2[C:7](=[N:8][C:13]([CH3:14])=[CH:10][CH:11]=2)[O:6][CH2:5]1

Participants

Reactant 2

HCID 722126836-Methyl-furo[2,3-B]pyridin-3-one

HCID 86721901furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime

Product 1

HCID 867219296-methylfuro[2,3-b]pyridin-3(2H)-one O-methyl oxime

Procedure

This compound was prepared using a method analogous to that of furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime (A.2.3.3), 6-methylfuro[2,3-b]pyridin-3(2H)-one replacing furo[2,3-c]pyridazin-5(6H)-one. Purification by (KP-SIL™ from Biotage) using Hept to Hept/EtOAc (1/1) gives the desired product as white solid;

Workup

customThis compound was prepared
customPurification by (KP-SIL™ from Biotage)

Sources & evidence

ORD record: ord-2269d0ca22524dbabab17fd6746b547a
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09221832B2

Reaction notes

Loading…