furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime → HCID 86721937, compound

Reaction equation

[CH3:1][O:2][N:3]=C1C2C=CN=NC=2OC1.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][N:18]=[C:17]2[O:21][CH2:22][C:23](=O)[C:16]=12>>[CH3:1][O:2][N:3]=[C:23]1[C:16]2[C:17](=[N:18][CH:19]=[CH:20][C:15]=2[O:14][CH3:13])[O:21][CH2:22]1

Participants

Reactant 2

HCID 86721901furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime

HCID 86721936HCID 86721936, compound

Product 1

HCID 86721937HCID 86721937, compound

Procedure

This compound was prepared using a method analogous to that of furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime (A.2.3.3), 4-methoxyfuro[2,3-b]pyridin-3(2H)-one replacing furo[2,3-c]pyridazin-5(6H)-one. Purification by (KP-SIL™ from Biotage) using Hept/EtOAc (1/1) gives the desired product as white solid;

Workup

customThis compound was prepared
customPurification by (KP-SIL™ from Biotage)

Sources & evidence

ORD record: ord-11f66c8881124181b00912b41d89ecf0
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09221832B2

Reaction notes

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