Sodium Hydroxide → (3S)-1-(2-fluoroethyl)-3-hydroxypyrrolidine
Reaction equation
[OH-].[Na+].[F:3][CH2:4][CH2:5][N:6]1[CH2:10][CH2:9][C@H:8]([O:11]C(=O)C)[CH2:7]1>CO>[F:3][CH2:4][CH2:5][N:6]1[CH2:10][CH2:9][C@H:8]([OH:11])[CH2:7]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4N aqueous sodium hydroxide solution (2 mL) was added to methanol (10 mL) solution of (3S)-1-(2-fluoroethyl)-3-acetoxypyrrolidine (507 mg, 2.89 mmols), and stirred at room temperature for an hour. The reaction liquid was concentrated under reduced pressure, extracted with chloroform and dried over anhydrous sodium sulfate. Concentrating the reaction liquid under reduced pressure, the title compound (135 mg, 35%) was obtained.
Workup
- customThe reaction liquid
- concentrationwas concentrated under reduced pressure
- extractionextracted with chloroform
- dry with materialdried over anhydrous sodium sulfate
- concentrationConcentrating
- customthe reaction liquid under reduced pressure
Sources & evidence
- ORD record
- ord-760412e2ac6c4faea17af6eff13e4d41
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07732456B2
Reaction notes
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