Ammonia → 3-Chlorobenzene-1-carboximidamide hydrochloride
Reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:9](=[NH:13])OCC)[CH:6]=[CH:7][CH:8]=1.[NH3:14]>>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[C:9]([NH2:13])=[NH:14]Participants
3
Procedure
A 18-mL vial was charged with ethyl 3-chlorobenzenecarboximidate hydrochloride (450 mg, 2 mmol, 1 eq.) and NH3 (2N in ethanol, 12 ml, 24 mmol, 12 eq.). The resulting mixture was stirred at rt overnight. The volatile material was removed under reduced pressure and the product thus obtained was forwarded to the next step without any further purification.
Workup
- customThe volatile material was removed under reduced pressure
- customthe product thus obtained
- customwas forwarded to the next step without any further purification
Sources & evidence
- ORD record
- ord-4d1cf10ee67a47b89e4b888b066b2fbe
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09221843B2
Reaction notes
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