HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → 5-chloro-thiophene-2-carboxylic acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Chloro-4-[(pyrrolidin-1-yl)carbonyl]aniline | HCID 16777853 | — |
| Reactant | 2-[(5-Chloro-thiophene-2-carbonyl)-amino]-propionic acid | HCID 43239338 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-chloro-thiophene-2-carboxylic acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide | HCID 11640731 | — |
Reaction Steps
Prepared analogously to Example 1a from 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid and 3-chloro-4-(pyrrolidin-1-yl-carbonyl)-aniline with TBTU and NMM in DMF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732466B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-dcdbdac0a56e40299e8b1ada792d2b70 |
| Source note | uspto-grants-2010_06 |