Tosylchloramide → HCID 12030321, compound
Reaction equation
[CH3:1][Si:2]1([CH3:7])[CH2:6][CH:5]=[CH:4][CH2:3]1.[Br-].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.[CH3:41][C:42]1[CH:43]=[CH:44][C:45]([S:48]([NH:51]Cl)(=[O:50])=[O:49])=[CH:46][CH:47]=1>C(#N)C>[CH3:1][Si:2]1([CH3:7])[CH2:6][CH:5]2[CH:4]([N:51]2[S:48]([C:45]2[CH:46]=[CH:47][C:42]([CH3:41])=[CH:43][CH:44]=2)(=[O:49])=[O:50])[CH2:3]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 1,1-dimethyl-2,5-dihydro-1H-silole (3.0 g, 26.7 mmol) in acetonitrile (50 mL) was added phenyltrimethylammonium tribromide (1.0 g, 2.67 mmol) and chloramine-T (6.69 g, 29.4 mmol). After stirring at rt overnight the reaction mixture was filtered though a pad of Celite and concentrated under vacuum. Purification by silica gel chromatography (20% EtOAc/hexanes) afforded the desired product.