Sodium Hydroxide → HCID 61834499, compound

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([NH:16]C(=O)C)[CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)=[O:9].[OH-].[Na+]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)=[O:9])[NH2:16]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 68637681N-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenyl]-acetamide

Product 1

HCID 61834499HCID 61834499, compound

Conditions

Temperature: 65 °C

Procedure

700.0 mg (2.67 mmol) N-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenyl]-acetamide are combined with 7 ml 4-molar sodium hydroxide solution and stirred overnight at 65° C. The reaction mixture is poured onto ice water and extracted with ethyl acetate. The organic phase is dried over magnesium sulphate and evaporated down i. vac.

Workup

additionThe reaction mixture is poured onto ice water
extractionextracted with ethyl acetate
dry with materialThe organic phase is dried over magnesium sulphate
customevaporated down i

Sources & evidence

ORD record: ord-0aa6374f81f648318495f33d600113bb
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07732466B2

Reaction notes

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