2-Fluoronaphthalene → 7-Methyl-4-(naphthalen-2-yloxy)-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine

HRID 1511692Notes

Reaction equation

HRID 1511692 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[CH:10]=[CH:11][O:12][C:4]=2[CH2:3]1.F[C:14]1[CH:23]=[CH:22][C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=1>>[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([O:9][C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)[C:5]2[CH:10]=[CH:11][O:12][C:4]=2[CH2:3]1

Participants

3

Reactant 2

HCID 675832-FluoronaphthaleneHCID 684096967-Methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol

Product 1

HCID 684132297-Methyl-4-(naphthalen-2-yloxy)-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine

Procedure

The same method as in Example 1 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 19) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-ff1a2eba645b4618955894554c9889cf
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

Loading…