3-Chloro-4-fluorobenzamide → 7-(4-Carbamoyl-2-chlorophenyloxy)-5-ethyl-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

HRID 1511751

Reaction equation

HRID 1511751 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]([OH:9])[C:6]2[S:10][C:11]([CH3:13])=[CH:12][C:5]=2[CH2:4]1)[CH3:2].[C:14]([C:17]1[CH:22]=[CH:21][C:20](F)=[C:19]([Cl:24])[CH:18]=1)(=[O:16])[NH2:15]>>[C:14]([C:17]1[CH:22]=[CH:21][C:20]([O:9][CH:7]2[CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][C:5]3[CH:12]=[C:11]([CH3:13])[S:10][C:6]2=3)=[C:19]([Cl:24])[CH:18]=1)(=[O:16])[NH2:15]

Participants

3

Reactant 2

HCID 27365203-Chloro-4-fluorobenzamideHCID 684124605-Ethyl-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol

Product 1

HCID 684127107-(4-Carbamoyl-2-chlorophenyloxy)-5-ethyl-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Procedure

The same method as in Example 1 was conducted using 5-ethyl-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 32) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-carbamoyl-2-chloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-a1c687e99a154769a98260c25d05d06e
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Linked notes

Loading…