4-Bromo-2-nitroaniline → (E)-N-(4-Bromo-2-nitro-phenyl)-3-(tetrahydro-pyran-4-yl)-acrylamide
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[O:12]1[CH2:17][CH2:16][CH:15](/[CH:18]=[CH:19]/[C:20](O)=[O:21])[CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:20](=[O:21])/[CH:19]=[CH:18]/[CH:15]2[CH2:16][CH2:17][O:12][CH2:13][CH2:14]2)=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1Participants
3
Procedure
Following the procedure as described in Example 3, STEP B, the title compound was prepared from 4-bromo-2-nitro-phenylamine (2.06 g, 9.47 mmol) and (E)-3-(tetrahydro-pyran-4-yl)-acrylic acid (prepared as described in PCT Publication WO 2005/101989 (A2,A3), 1.14 g, 7.29 mmol) and was obtained as a yellow solid.
Workup
- customwas obtained as a yellow solid
Sources & evidence
- ORD record
- ord-fad9cab1ccca4465ae610a2db0dd98df