Bromine → 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione
Reaction equation
[Br:1]Br.[N:3]1[NH:4][C:5](=[O:10])[NH:6][C:7](=[O:9])[CH:8]=1>O>[Br:1][C:8]1[C:7](=[O:9])[NH:6][C:5](=[O:10])[NH:4][N:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Bromine (2.506 mL, 48.6 mmol) was added to a suspension of 1,2,4-triazine-3,5(2H,4H)-dione (commercially available from Aldrich, 2.5 g, 22.11 mmol) in Water (40 mL). The mixture was stirred at room temperature for 26 hours. A white precipitate was formed. The solid was recovered by filtration and recrystallized from water (15 mL at reflux temperature) affording the title compound 6-bromo-1,2,4-triazine-3,5(2H,4H)-dione (1.97 g, 10.26 mmol, 46.4% yield) as a white crystalline solid.
Workup
- customA white precipitate was formed
- filtrationThe solid was recovered by filtration
- customrecrystallized from water (15 mL at reflux temperature)
Sources & evidence
- ORD record
- ord-92d153988cc04c6699b8fd7739c1907d
- Source dataset
- uspto-grants-2012_07
- Patent number
- US08217168B2
Reaction notes
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