[OH-].[Na+].[C:3]([C:5]1[CH:6]=[C:7]([C:15]2[O:19][N:18]=[C:17]([C:20]3[C:30]4[O:29][CH2:28][CH2:27][N:26]([CH2:31][CH2:32][CH2:33][CH2:34][C:35]([O:37]CC)=[O:36])[CH2:25][C:24]=4[CH:23]=[CH:22][CH:21]=3)[N:16]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH:12]([CH3:14])[CH3:13])#[N:4]>C(O)C>[C:3]([C:5]1[CH:6]=[C:7]([C:15]2[O:19][N:18]=[C:17]([C:20]3[C:30]4[O:29][CH2:28][CH2:27][N:26]([CH2:31][CH2:32][CH2:33][CH2:34][C:35]([OH:37])=[O:36])[CH2:25][C:24]=4[CH:23]=[CH:22][CH:21]=3)[N:16]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH:12]([CH3:14])[CH3:13])#[N:4]2M sodium hydroxide (0.347 mL, 0.694 mmol) was added to a stirred solution of ethyl 5-[9-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]pentanoate (Preparation 93) (70 mg, 0.139 mmol) in ethanol (5 mL) and the mixture was heated to 60° C. overnight. The reaction mixture was allowed to cool to room temperature and the solvent evaporated. The residue was diluted with water, acidified with 2M hydrochloric acid and extracted with ethyl acetate. The organic phase was washed with water, dried and evaporated to give the product as an off white solid (20 mg).
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