Morpholine → 6-Chloro-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-2-amine
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]=[C:7]([NH2:17])[N:8]=[C:9]([N:12]3[CH:16]=NC=N3)[C:10]=2[N:11]=1.N1C[CH2:22][O:21][CH2:20][CH2:19]1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]=[C:7]([NH2:17])[N:8]=[C:9]([N:12]3[CH2:16][CH2:22][O:21][CH2:20][CH2:19]3)[C:10]=2[N:11]=1Participants
4
Procedure
A suspension of 6-chloro-4-[1,2,4]triazol-1-yl-pyrido[3,2-d]pyrimidin-2-ylamine (0.1 g, 0.4 mmol) and morpholine (0.07 mL, 0.8 mmol) in DCM (10 mL) was stirred at room temperature for 48 hours. After the removal of solvent, the residue was purified by flash chromatography (using 5% i-PrOH/DCM as the eluent), providing the title compound (0.26 g, 99% yield) as a yellow solid which was characterised as follows: MS (m/z) 266.0 [M+H]+.