1-Chloro-3,5-dinitrobenzene → 1-Chloro-3-methoxy-5-nitrobenzene

HRID 1517950Notes

Reaction equation

HRID 1517950 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N+]([O-])=O)[CH:5]=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1.[CH3:14][O-:15].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[C:6]([O:15][CH3:14])[CH:5]=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1

Participants

4

Reactant 2

HCID 330981-Chloro-3,5-dinitrobenzeneHCID 10942334Sodium Methoxide

Product 1

HCID 140260501-Chloro-3-methoxy-5-nitrobenzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

11.1 g 1-chloro-3,5-dinitrobenzene are dissolved in 100 ml of methanol and combined with 3 g sodium methoxide. Then the mixture is refluxed for 48 hours, cooled to ambient temperature and the solid is suction filtered.

Workup

  1. temperatureThen the mixture is refluxed for 48 hours
  2. filtrationfiltered

Sources & evidence

ORD record
ord-00a8e4c3ad574813b5d170d02c342a23
Source dataset
uspto-grants-2012_07
Patent number
US08232312B2

Reaction notes

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