Methylhydrazine → 3'-Fluoro-6'-methyl-2,2'-bipyridin-4-amine
Reaction equation
[F:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([N:15]3C(=O)C4C(=CC=CC=4)C3=O)[CH:12]=[CH:11][N:10]=2)=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.CNN>ClCCl>[F:1][C:2]1[C:3]([C:9]2[CH:14]=[C:13]([NH2:15])[CH:12]=[CH:11][N:10]=2)=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-(3′-fluoro-6′-methyl-2,2′-bipyridin-4-yl)isoindoline-1,3-dione (65 mg, 0.195 mmol) was suspended in dichloromethane (3 mL); methylhydrazine (0.205 mL, 3.90 mmol) was added and the mixture was stirred at room temperature over night. The reaction was filtered thru Celite® and the filtrate was concentrated to give the title compound as a clear yellow film which was used without further purification. ESI-MS: m/z 204.1 (M+H).