2-Bromobenzenethiol → 4-Hydroxy-4-(2-mercapto-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

HRID 15228

Reaction equation

BrC1C=CC=CC=1S.C(OC(N1CCC(=O)CC1)=O)(C)(C)C.[C:23]([O:27][C:28]([N:30]1[CH2:35][CH2:34][C:33]([C:37]2[CH:42]=[C:41](F)[CH:40]=[CH:39][C:38]=2[SH:44])([OH:36])[CH2:32][CH2:31]1)=[O:29])([CH3:26])([CH3:25])[CH3:24]>>[C:23]([O:27][C:28]([N:30]1[CH2:31][CH2:32][C:33]([OH:36])([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[SH:44])[CH2:34][CH2:35]1)=[O:29])([CH3:26])([CH3:24])[CH3:25]

Participants

Reactant 3

HCID 805982-Bromobenzenethiol

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

HCID 686821134-(5-Fluoro-2-mercapto-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 686822154-Hydroxy-4-(2-mercapto-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Procedure

This intermediate was prepared from 2-bromo-benzenethiol and 4-oxo-piperidine-1-carboxylic acid tert-butyl ester in a similar way as described for 4-(5-fluoro-2-mercapto-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record: ord-b73883d285c14f8994f382c64271343a
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07732463B2

Linked notes

Loading…