Water → 2-(2-Fluoro-3-methoxyphenyl)acetic acid
Reaction equation
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:10][C:11]#N.[OH-:13].[Na+].[OH2:15]>CO>[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:10][C:11]([OH:15])=[O:13]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 60 °C
Procedure
To a mixture of 2-(2-fluoro-3-methoxyphenyl)acetonitrile (6.7 g, 40.6 mmol) in water (40 mL) and methanol (40 mL), sodium hydroxide (3.2 g, 81.1 mmol) was added. The resulting mixture was stirred at 60° C. for 5 h. After cooling to room temperature, methanol was evaporated under reduced pressure. The residue was acidified with 10% HCl until pH 5. The resulting precipitate was collected by filtration and dried to afford the title compound (6.3 g).
Workup
- additionwas added
- temperatureAfter cooling to room temperature
- custommethanol was evaporated under reduced pressure
- filtrationThe resulting precipitate was collected by filtration
- customdried
Sources & evidence
- ORD record
- ord-82204c55c96e44a0a106ecb371bd5bbf
- Source dataset
- uspto-grants-2015_07
- Patent number
- US09078871B2
Reaction notes
Loading…