1-Bromopropane → 5,7-Dichloro-1-propylindoline-2,3-dione

HRID 1523027

Reaction equation

HRID 1523027 reaction equation
[CH2:1](N1C2C(=CC=CC=2)C(=O)C1=O)[CH2:2][CH3:3].[Cl:15][C:16]1[CH:17]=[C:18]2[C:22](=[C:23]([Cl:25])[CH:24]=1)[NH:21][C:20](=[O:26])[C:19]2=[O:27].BrCCC>>[Cl:15][C:16]1[CH:17]=[C:18]2[C:22](=[C:23]([Cl:25])[CH:24]=1)[N:21]([CH2:1][CH2:2][CH3:3])[C:20](=[O:26])[C:19]2=[O:27]

Participants

4

Reactant 3

HCID 78401-BromopropaneHCID 807715,7-Dichloro-1H-indole-2,3-dioneHCID 16450901-propyl-1H-indole-2,3-dione

Product 1

HCID 188037825,7-Dichloro-1-propylindoline-2,3-dione

Procedure

Was made in an analogous fashion to 1-propylindoline-2,3-dione using 5,7-dichloroisatin (purchased from Fisher Scientific) and 1-bromopropane (purchased from Fisher Scientific). 1H NMR δ 7.53 (d, 1H), 7.51 (d, 1H), 4.05 (t, 2H), 1.78 (m, 2H), 0.99 (t, 3H).

Sources & evidence

ORD record
ord-10b6746ce5ad4288be50778695748133
Source dataset
uspto-grants-2015_07
Patent number
US09079853B2

Linked notes

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