1-Fluoro-3-iodobenzene → 1-tert-Butoxycarbonyl-4-[2-(3-fluoro-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-ol

HRID 15231

Reaction equation

HRID 15231 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]([OH:22])([C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=2[SH:21])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26](I)[CH:25]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][C:11]([C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=2[S:21][C:26]2[CH:27]=[CH:28][CH:29]=[C:24]([F:23])[CH:25]=2)([OH:22])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 707251-Fluoro-3-iodobenzeneHCID 686821134-(5-Fluoro-2-mercapto-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 686876731-tert-Butoxycarbonyl-4-[2-(3-fluoro-phenylsulfanyl)-5-fluoro-phenyl]-piperidine-4-ol

Procedure

Prepared from 4-hydroxy-4-(2-mercapto-5-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester and 1-fluoro-3-iodo-benzene.

Sources & evidence

ORD record
ord-7f7deea65be14ba2a2c74730c48fc900
Source dataset
uspto-grants-2010_06
Patent number
US07732463B2

Linked notes

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