5-Fluoro-2-iodobenzoic acid → 5-Methoxy-2-(2H-1,2,3-triazol-2-yl)benzoic acid
Reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].IC1C=CC(OC)=CC=1[C:19](O)=[O:20].FC1C=CC(I)=C(C=1)C(O)=O>>[CH3:19][O:20][C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]Participants
4
Procedure
The title compound was prepared in a manner analogous to Intermediate 1, substituting for 2-iodo-5-methoxy benzoic acid for 5-fluoro-2-iodo-benzoic acid in Step A. 1H NMR (400 MHz, CD3OD): 7.81 (s, J=6.4, 2H), 7.55 (d, J=8.8, 1H), 7.33 (d, J=2.9, 1H), 7.18 (dd, J=8.8, 2.9, 1H), 3.85 (s, 3H).
Sources & evidence
- ORD record
- ord-1a91177549cc46f7b0250bb1abc17fd7
- Source dataset
- uspto-grants-2015_07
- Patent number
- US09079911B2
Reaction notes
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