HCID 118232987, compound → 3-(3-chloro-4-methyl-1H-pyrazol-1-yl)pyridine

HRID 1525774Notes

Reaction equation

HRID 1525774 reaction equation
[Cl:1][C:2]1[CH:6]([CH3:7])[CH2:5][N:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)[N:3]=1>C(#N)C.[O-2].[Mn+4].[O-2]>[Cl:1][C:2]1[C:6]([CH3:7])=[CH:5][N:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)[N:3]=1

Participants

4

Reactant 1

HCID 118232987HCID 118232987, compound

Product 1

HCID 216244353-(3-chloro-4-methyl-1H-pyrazol-1-yl)pyridine

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6342AcetonitrileSolvent

Conditions

Temperature
40 °C

Procedure

In another embodiment, 3-(3-chloro-4-methyl-4,5-dihydro-1H-pyrazol-1-yl)pyridine (2) in acetonitrile is oxidized with manganese(IV) oxide and the mixture is heated at about 40° C. The 3-(3-chloro-4-methyl-1H-pyrazol-1-yl)pyridine (3) can be isolated and purified by standard techniques.

Sources & evidence

ORD record
ord-0d3d1ee38e4541febb05ef65477f742a
Source dataset
uspto-grants-2015_07
Patent number
US09085552B1

Reaction notes

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