Water → HCID 86705825, compound

HRID 1525775

Reaction equation

HRID 1525775 reaction equation
[Cl:1][C:2]1[C:6]([CH3:7])=[CH:5][N:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)[N:3]=1.[Mn]([O-])(=O)(=O)=[O:15].[Na+].[OH2:20]>C(O)(C)(C)C>[Cl:1][C:2]1[C:6]([C:7]([OH:15])=[O:20])=[CH:5][N:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)[N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 21624435HCID 21624435, compoundHCID 23673458Sodium Permanganate

Product 1

HCID 86705825HCID 86705825, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Conditions

Temperature
80 °C

Procedure

In another embodiment, 3-(3-chloro-4-methyl-1H-pyrazol-1-yl)pyridine (3) is further oxidized by sodium permanganate in water and tert-butanol and heated at about 80° C. The 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid (4) can be isolated and purified by standard techniques.

Sources & evidence

ORD record
ord-0a85856c3b0744918ac295d197ba25ca
Source dataset
uspto-grants-2015_07
Patent number
US09085552B1

Linked notes

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