Water → HCID 86705825, compound

Temperature

80 °C

To a mixture of 3-(3-chloro-4-methyl-4,5-dihydro-1H-pyrazol-1-yl)pyridine (2.0 g, 10 mmol) in water (10.0 mL) and tert-butanol (5.0 mL) was added a solution of sodium permanganate (NaMnO4) (5.0 g, 35 mmol) in water (15 mL) over 20 minutes. The mixture was heated to 80° C. and stirred overnight. Additional sodium permanganate (0.711 g, 5.0 mmol) in water (2.0 mL) was added after 16 hours and the mixture was stirred for another 4 hours. The dark mixture was filtered through Celite®, washed with water (5.0 mL) and ethyl acetate (3×15 mL). The aqueous layer was extracted with ethyl acetate (25 mL) and acidified with concentrated hydrochloric acid to pH 5 leading to white precipitate which was collected by filtration. The filtrate was concentrated leading to white precipitate which was collected by filtration and washed with water (2.0 mL). The solid products were combined and dried under high vacuum to afford the title compound as a white solid (1.0 g, 46%): 1H NMR (400 MHz, DMSO-d6) δ 9.11 (s, 2H), 8.59 (d, J=4.7, 1H), 8.28 (ddd, J=8.4, 2.7, 1.4 Hz, 1H), 7.58 (dd, J=8.0, 4.4 Hz, 1H); 13C NMR (101 MHz, DMSO-d6) δ 162.24, 148.35, 141.46, 140.21, 135.01, 134.01, 126.45, 124.23, 115.34; ESIMS m/z 224 ([M+H]+).

1. stirringthe mixture was stirred for another 4 hours
2. filtrationThe dark mixture was filtered through Celite®
3. washwashed with water (5.0 mL) and ethyl acetate (3×15 mL)
4. extractionThe aqueous layer was extracted with ethyl acetate (25 mL)
5. filtrationwas collected by filtration
6. concentrationThe filtrate was concentrated
7. filtrationwas collected by filtration
8. washwashed with water (2.0 mL)
9. customdried under high vacuum

ORD record

ord-b0935a88b5dc47b9a2adf3ce09cc5165

Source dataset

uspto-grants-2015_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09085552B1