4-(Aminomethyl)-N-(3-pyridinyl)benzamide dihydrobromide → 4-(Aminomethyl)-N-(pyridin-3-YL)benzamide
Reaction equation
Br.Br.[NH2:3][CH2:4][C:5]1[CH:19]=[CH:18][C:8]([C:9]([NH:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[O:10])=[CH:7][CH:6]=1>N>[NH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:9]([NH:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[O:10])=[CH:18][CH:19]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A suspension of dihydrobromide salt 32 (1 mmol) in dilute aqueous ammonia solution (50 mL) was extracted into CHCl3 (3×50 mL), the organic fraction dried and the solvent evaporated to give crude benzamide 33 which was used directly.
Workup
- extractionwas extracted into CHCl3 (3×50 mL)
- customthe organic fraction dried
- customthe solvent evaporated
Sources & evidence
- ORD record
- ord-2cdd3bf152864df0a5f58f3ac34e5f91
- Source dataset
- uspto-grants-2015_07
- Patent number
- US09085570B2
Reaction notes
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