7-Methoxy-3-indolecarboxaldehyde → (3-Carbamoyl-7-methoxy-indol-1-yl)-acetic acid
Reaction equation
[CH3:1][O:2]C1C=CC=C2C=1NC=C2C=O.[C:14]([C:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23](Cl)[CH:24]=2)[N:19]([CH2:27][C:28]([OH:30])=[O:29])[CH:18]=1)(=[O:16])[NH2:15]>>[C:14]([C:17]1[C:25]2[C:20](=[C:21]([O:2][CH3:1])[CH:22]=[CH:23][CH:24]=2)[N:19]([CH2:27][C:28]([OH:30])=[O:29])[CH:18]=1)(=[O:16])[NH2:15]Participants
3
Procedure
was prepared from 7-methoxy-1H-indole-3-carbaldehyde [109021-59-2] in a similar manner as described in Scheme A11 for the preparation of (3-carbamoyl-5-chloro-indol-1-yl)-acetic acid. White solid. MS (LC/MS): 249 [M+H]+, 497 [2M+H]+; tR (HPLC conditions c): 3.05 min.
Workup
- custom3.05 min.
Sources & evidence
- ORD record
- ord-b23f6c0486fc4975a5cec746e43eff07
- Source dataset
- uspto-grants-2015_07