6-(Difluoromethoxy)-1H-indole → (3-Carbamoyl-6-difluoromethoxy-indol-1-yl)-acetic acid
Reaction equation
[F:1][CH:2]([F:13])[O:3]C1C=C2C(C=CN2)=CC=1.[C:14]([C:17]1[C:25]2[C:20](=[CH:21][C:22](F)=[C:23](F)[CH:24]=2)[N:19]([CH2:28][C:29]([OH:31])=[O:30])[CH:18]=1)(=[O:16])[NH2:15]>>[C:14]([C:17]1[C:25]2[C:20](=[CH:21][C:22]([O:3][CH:2]([F:13])[F:1])=[CH:23][CH:24]=2)[N:19]([CH2:28][C:29]([OH:31])=[O:30])[CH:18]=1)(=[O:16])[NH2:15]Participants
3
Procedure
was prepared from 6-difluoromethoxy-1H-indole [200207-21-2] in a similar manner as described for the preparation of (3-carbamoyl-5,6-difluoro-indol-1-yl)acetic acid. White solid. MS (LC/MS): 285 [M+H]+, 569 [2M+H]+; tR (HPLC conditions k): 2.64 min.
Workup
- custom2.64 min.
Sources & evidence
- ORD record
- ord-ac00b4c1942c4ac0aad6262bb3868388
- Source dataset
- uspto-grants-2015_07