4-Chlorobenzonitrile → 1-(4-Chlorophenyl)cyclopropanamine

Reaction equation

Cl[C:2]1[CH:3]=[C:4]([C:8]2([NH2:11])[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[Cl:12]C1C=CC(C#N)=CC=1>>[Cl:12][C:7]1[CH:6]=[CH:5][C:4]([C:8]2([NH2:11])[CH2:10][CH2:9]2)=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 121634-Chlorobenzonitrile

HCID 110842701-(3-Chlorophenyl)cyclopropanamine

Product 1

HCID 113442131-(4-Chlorophenyl)cyclopropanamine

Procedure

was prepared using the same procedure as for the preparation of 1-(3-chloro-phenyl)-cyclopropylamine starting from 4-chlorobenzonitrile. MS (UPLC-MS): 170 [M+H]+, 168 [M−H]; tR (HPLC conditions f): 1.21 min.

Workup

customwas prepared
custom1.21 min.

Sources & evidence

ORD record: ord-8efeb5516c974e4aa777c95750a7d508
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09085555B2

Reaction notes

Loading…