HCID 86686556, compound → HCID 86686557, compound
Reaction equation
[F:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH3:16])([CH3:15])[C:5](=[O:14])[NH:6]2>[Pd].CO>[NH2:11][C:10]1[C:2]([F:1])=[C:3]2[C:7](=[CH:8][CH:9]=1)[NH:6][C:5](=[O:14])[C:4]2([CH3:15])[CH3:16]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A suspension of 4-fluoro-3,3-dimethyl-5-nitro-1,3-dihydro-2H-indol-2-one (3.5 g), palladium on carbon (containing water (50%), 2.0 g) in methanol (150 mL) was stirred at room temperature for 3 hr under a hydrogen atmosphere. The palladium on carbon was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (2.9 g).
Workup
- customThe palladium on carbon was removed by filtration
- concentrationthe filtrate was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-d1901db62d9f45908933aa299b6b072e
- Source dataset
- uspto-grants-2015_07
- Patent number
- US09090586B2
Reaction notes
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