6-Chloro-3-nitropyridin-2-ol → 3-Amino-6-chloro-pyridin-2-ol
Reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([OH:8])[C:5]([NH:9]C2C(=O)C(=O)C=2NC(C2OC(C)=CC=2)C2(C)COC2)=[CH:4][CH:3]=1.ClC1NC(=O)C([N+]([O-])=O)=CC=1>>[NH2:9][C:5]1[C:6](=[O:8])[NH:7][C:2]([Cl:1])=[CH:3][CH:4]=1Participants
3
Procedure
In a manner analogous to EXAMPLE 1 (steps 1 to 3, 6 and 7), 3-(6-chloro-2-hydroxypyridin-3-ylamino)-4-{[(5-methylfuran-2-yl)-(3-methyloxetan-3-yl)methyl]amino}cyclobut-3-ene-1,2-dione was prepared from 6-chloro-3-nitro-1H-pyridin-2-one. HPLC 94.8%, ES− [402].
Sources & evidence
- ORD record
- ord-28f6e12974cd473aab2d54baa2f61156
- Source dataset
- uspto-grants-2015_07
- Patent number
- US09090596B2
Reaction notes
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