Pyridine → 7-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-3-carboxylic acid ethyl ester

HRID 152892

Reaction equation

HRID 152892 reaction equation
[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]2[cH:10][c:11]([NH2:16])[cH:12][cH:13][c:14]2[cH:15]1.[CH:42]([Cl:43])([Cl:44])[Cl:45].[F:23][C:24]([c:25]1[cH:26][cH:27][c:28](-[c:31]2[c:32]([C:37](=[O:38])[Cl:39])[cH:33][cH:34][cH:35][cH:36]2)[cH:29][cH:30]1)([F:40])[F:41].[cH:17]1[cH:18][cH:19][n:20][cH:21][cH:22]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]2[cH:10][c:11]([NH:16][C:37]([c:32]3[c:31](-[c:28]4[cH:27][cH:26][c:25]([C:24]([F:23])([F:40])[F:41])[cH:30][cH:29]4)[cH:36][cH:35][cH:34][cH:33]3)=[O:38])[cH:12][cH:13][c:14]2[cH:15]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6212ChloroformHCID 9877801Ethyl 7-aminoquinoline-3-carboxylateHCID 110660004'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl chloride

Product 1

HCID 101832717-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-3-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-984da8a864474ff390dd50aaef3cae25
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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