Formaldehyde → 3-Benzyloxypropylhydroxymethylphosphinic acid, n-butyl ester

Reaction equation

[CH2:1]([O:5][PH:6]([CH2:8][CH2:9][CH2:10][O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:7])[CH2:2][CH2:3][CH3:4].[CH2:19]=[O:20]>>[CH2:12]([O:11][CH2:10][CH2:9][CH2:8][P:6]([CH2:19][OH:20])(=[O:7])[O:5][CH2:1][CH2:2][CH2:3][CH3:4])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

Reactant 2

HCID 712Formaldehyde

HCID 178418338HCID 178418338, compound

Product 1

HCID 867521933-Benzyloxypropylhydroxymethylphosphinic acid, n-butyl ester

Procedure

The title compound was prepared from 3-benzyloxypropylphosphinic acid n-butyl ester and paraformaldehyde according to the method described in Procedure 31. Purification by chromatography, eluting with dichloromethane containing 5% methanol, gave an oil.

Workup

customPurification by chromatography
washeluting with dichloromethane containing 5% methanol
customgave an oil

Sources & evidence

ORD record: ord-5e782fbe5d444dfdbc8456bc63b99809
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05726165

Reaction notes

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