Tricyclo(3.3.1.13,7)dec-1-ylmethylamine → 2-Chloro-5-fluoro-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide
Reaction equation
[C:1]12([CH2:11][NH2:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[Cl:13][C:14]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:15]=1[C:16](O)=[O:17]>>[Cl:13][C:14]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:15]=1[C:16]([NH:12][CH2:11][C:1]12[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH2:2]1)[CH2:10]2)=[O:17]Participants
3
Procedure
Prepared according to the method of Example 41 from 1-adamantanemethylamine (0.1 ml) and 2-chloro-5-fluorobenzoic acid (0.098 g) to give the title compound as a white solid (0.165 g).
Workup
- customPrepared
Sources & evidence
- ORD record
- ord-fe585f55767c48ffa8bd0348ff1f5ca9
- Source dataset
- uspto-grants-2001_03