L-Methionine, methyl ester, hydrochloride → [4-(2-Thienylmethoxymethyl)-2-(2-methylphenyl)benzoyl]methionine methyl ester

HRID 1532852

Reaction equation

HRID 1532852 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][O:7][CH2:8][C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[C:11]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])[CH:10]=1.Cl.[CH3:26][O:27][C:28](=[O:35])[C@H:29]([CH2:31][CH2:32][S:33][CH3:34])[NH2:30]>>[CH3:26][O:27][C:28](=[O:35])[C@H:29]([CH2:31][CH2:32][S:33][CH3:34])[NH:30][C:13](=[O:14])[C:12]1[CH:16]=[CH:17][C:9]([CH2:8][O:7][CH2:6][C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[CH:10][C:11]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[CH3:24]

Participants

3

Reactant 2

HCID 11435579L-Methionine, methyl ester, hydrochlorideHCID 220143364-(2-Thienylmethoxymethyl)-2-(2-methylphenyl)benzoic acid

Product 1

HCID 70224587[4-(2-Thienylmethoxymethyl)-2-(2-methylphenyl)benzoyl]methionine methyl ester

Procedure

The desired compound was prepared by coupling 4-(2-thienylmethoxymethyl)-2-(2-methylphenyl)benzoic acid, prepared as in Example 272C, with methionine methyl ester hydrochloride using the procedure of Example 184A.

Sources & evidence

ORD record
ord-f3bdfc3ee6324a73a74eb4122e73f881
Source dataset
uspto-grants-2001_03
Patent number
US06204293B1

Linked notes

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