Potassium Iodide → 5-[2-[4-(2,6-Dimethylphenyl)-1-Piperazinyl]Ethyl]-3-Methyl-2-Oxazolidinone

HRID 1533925

Reaction equation

HRID 1533925 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.Cl[CH2:16][CH2:17][CH:18]1[O:22][C:21](=[O:23])[N:20]([CH3:24])[CH2:19]1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+].C(OC(C)C)(C)C.CC(O)C>C(O)CCC>[CH3:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:16][CH2:17][CH:18]2[O:22][C:21](=[O:23])[N:20]([CH3:24])[CH2:19]2)[CH2:13][CH2:14]1

Participants

7

Reactant 5

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 705381-(2,6-Xylyl)piperazineHCID 146987465-(2-Chloro-ethyl)-3-methyl-oxazolidin-2-oneHCID 21202047Isopropyl alcohol isopropyl ether

Product 1

HCID 150300895-[2-[4-(2,6-Dimethylphenyl)-1-Piperazinyl]Ethyl]-3-Methyl-2-OxazolidinoneYield 57%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

This compound was prepared according to the procedure of Example 2. A mixture of 3.8 g (0.02 mol) of 1-(2,6-dimethylphenyl)piperazine (Emka-Chemie), 3.3 g (0.02 mol) of 5-(2-chloroethyl)-3-methyl-2-oxazolidinone, 6.4 g (0.06 mol) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 mL of 1-butanol gave 3.6 g (57%) of white solid, mp 107°-108° C. (isopropyl ether/2-propanol).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-b62e597d7b3744d1825b02b12c0f2459
Source dataset
uspto-grants-1992_02
Patent number
US05086055

Linked notes

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