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Pyridinium chloride → (2-hydroxyphenyl)-(1-methyl-1H-indol-4-yl) methanone

HRID 1533991
Notes
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Reaction equation

HRID 1533991 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][N:15]2[CH3:20])=[O:10].Cl.N1C=CC=CC=1>C(Cl)Cl>[OH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]=[CH:14][N:15]2[CH3:20])=[O:10]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 67854483(2-methoxyphenyl)-(1-methyl-1H-indol-4-yl) methanone

Product 1

HCID 67854425(2-hydroxyphenyl)-(1-methyl-1H-indol-4-yl) methanoneYield 60.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using the procedure of Step C of Example 3, 29.9 g of the product of Step C and 300 g of pyridine hydrochloride were reacted to obtain using methylene chloride as eluant for the chromatography 17.2 g of the expected product melting at 80° C. which was used as is for the following step.

Workup

  1. customwere reacted
  2. customto obtain

Sources & evidence

ORD record
ord-14a029a606614662ae77a4507290ca01
Source dataset
uspto-grants-1992_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05086070

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes