Aluminum(III) Chloride → 2,3-Difluoro-4-hydroxybenzonitrile
Reaction equation
C([O:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[C:6]([F:12])[C:5]=1[F:13])C.[Cl-].[Al+3].[Cl-].[Cl-]>C1(C)C=CC=CC=1>[C:8]([C:7]1[CH:10]=[CH:11][C:4]([OH:3])=[C:5]([F:13])[C:6]=1[F:12])#[N:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 0.1 mol of 4-ethoxy-2,3-difluoro benzonitrile in 100 ml of toluene is slowly added dropwise at room temperature in the course of 30 minutes to a solution of 0.1 mol of aluminium(III) chloride in 100 ml of toluene. The mixture is subsequently heated to boiling for 5 hours and worked up as customary after cooling, m.p.: 145° C.
Workup
- temperatureThe mixture is subsequently heated
- temperatureafter cooling
Sources & evidence
- ORD record
- ord-37ba483e93304af2bc653087b067a85a
- Source dataset
- uspto-grants-1992_02
- Patent number
- US05087764
Reaction notes
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